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Information for parents and children about what to eat to reduce the chances of side effects while taking prednisone. Prednisone is a medication a steroid drug that is prescribed by your doctor for some diseases. While you are taking prednisone you will need to change what you eat and drink. This resource will explain what to eat and drink while you are taking prednisone to help lessen these side effects. We get sodium from the foods we eat, and most of it comes from salt. Sodium helps to control the amount of water in our bodies as well as our blood pressure. You need to eat foods that are low in sodium because prednisone can cause you to hold extra water in your body. This causes swelling or puffiness, usually around your eyes and ankles. Too much salt in your diet can make this problem worse.